LISTING OF MENTAL HEALTH
RELATED PUBLICATIONS AND REFERENCES

as at November 2019

asd, biobalance, autism, pyrrole
E

Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis

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Biomarker Case-Detection and Prediction with Potential for Functional Psychosis Screening: Development and Validation of a Model Related to Biochemistry, Sensory Neural Timing and End Organ Performance.

Fryar-Williams S, Strobel JE.
https://www.ncbi.nlm.nih.gov/pubmed/27148083

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Fundamental Role of Methylenetetrahydrofolate Reductase 677 C → T Genotype and Flavin Compounds in Biochemical Phenotypes for Schizophrenia and Schizoaffective Psychosis

Fryar-Williams S, Strobel JE.
https://www.ncbi.nlm.nih.gov/pubmed/27148083

E

Database Analysis of Depression and Anxiety in a Community Sample—Response to a Micronutrient Intervention

Samantha M. Kimball, Naghmeh Mirhosseini, and Julia Rucklidge
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5852728/

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Micronutrient Therapy for Violent Aggressive Male Youth

Jessica L. Hambly, MPharm (Hons),1 Kelly Francis, MBBS, FRACGP,2 Sohil Khan, PhD,1,3
Kristen S. Gibbons, PhD, AStat,3 William J. Walsh, PhD,4 Brett Lambert, MAppSc,5
Chris Testa, BPharm, BBus,6 and Alison Haywood, PhD1,3
https://www.ncbi.nlm.nih.gov/pubmed/28481642

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Brain-specific epigenetic markers of schizophrenia

VLJ Whitehall, RM Young, J Voisey
https://www.nature.com/articles/tp2015177

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The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis.

Psychol Med.2017 Jul;47(9):1515-1527. doi: 10.1017/S0033291717000022. Epub 2017 Feb 16.
Firth J1Stubbs B2Sarris J3Rosenbaum S4Teasdale S5Berk M6Yung AR1.

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Diet and Psychosis: A Scoping Review.

Neuropsychobiology.2018 Oct 25:1-23. doi: 10.1159/000493399. [Epub ahead of print]
Aucoin M1LaChance L2,3Cooley K1,4Kidd S2

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Alterations of serum macro-minerals and trace elements are associated with major depressive disorder: a case-control study.

BMC Psychiatry.2018 Apr 10;18(1):94. doi: 10.1186/s12888-018-1685-z.
Islam MR1Islam MR2Shalahuddin Qusar MMA3Islam MS4Kabir MH5Mustafizur Rahman GKM5Islam MS2Hasnat A2.

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Association between Lower Intake of Minerals and Depressive Symptoms among Elderly Japanese Women but Not Men: Findings from Shika Study.

Nutrients. 2019 Feb 13;11(2). pii: E389. doi: 10.3390/nu11020389.
Thi Thu Nguyen T1Miyagi S2Tsujiguchi H3Kambayashi Y4Hara A5Nakamura H6Suzuki K7Yamada Y8Shimizu Y9Nakamura H10.

Zinc:

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Zinc in CNS: From Molecules to Behaviour. “Biofactors” 2012 Mar 31

Covered role of zinc in transcription factors, gene regulation, transporters, neurogenesis, neurotransmission, AD, Depression, Stroke, Epilepsy. This paper alone had 81 references

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Zinc supplementation in Major Depression: A RCT. Iran J Psychiatry. 2013 June 8, 73—79

SSRI plus zinc is more effective than SSRI plus placebo in treating depression. This paper alone had 26 reference articles

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Zinc in Depression, A Meta-Analysis: Biological Psychiatry: 2013, Dec15, pp872—878

Considered 17 studies in 1643 patients
Concluded:

    • Zinc concentrations 1.85micm/l lower in depressed patients.
    • The lower the zinc concentration the more severe the depression.
    • Low zinc levels are a marker of treatment resistant depression.
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Do the Micronutrients Zinc and Magnesium Play a Role in Adult Depression?

Top Clin Nutr.2011 Jul-Sep;26(3):257-267. doi: 10.1097/TIN.0b013e3182260d86.
Dickerman B1Liu J1

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Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action.

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The role of magnesium and zinc in depression: similarities and differences.

Magnes2018 Aug 1;31(3):78-89. doi: 10.1684/mrh.2018.0442.
Szewczyk B1Szopa A2Serefko A2Poleszak E2Nowak G3.

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Do the Micronutrients Zinc and Magnesium Play a Role in Adult Depression?

Top Clin Nutr.2011 Jul-Sep;26(3):257-267. doi: 10.1097/TIN.0b013e3182260d86.
Dickerman B1Liu J1.

Magnesium:

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Association between magnesium intake and depression: Australian & New Zealand Journal of Psychiatry: Volume 43, 2009

5708 patients. “There is an inverse statistically significant association between dietary magnesium intake and depression score”
There seemed to be a similar association with anxiety but not statistically significant.

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Magnesium and depression: A Systematic Review. Nutritional Neuroscience, Vol 16, 2013.

21 cross sectional studies, 3 interventional studies, one prospective trial.
“A higher dietary intake of magnesium is associated with lower depression symptoms.”

E

Magnesium and depression.

Magnes2016 Mar 1;29(3):112-119.
Serefko A1Szopa A1Poleszak E1.

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Do the Micronutrients Zinc and Magnesium Play a Role in Adult Depression?

Mg-Intro..NMDA.. Top Clin Nutr.2011 Jul-Sep;26(3):257-267. doi: 10.1097/TIN.0b013e3182260d86.
Dickerman B1Liu J1

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The Role of Magnesium in Neurological Disorders.

2018 Jun 6;10(6). pii: E730. doi: 10.3390/nu10060730.
Kirkland AE1Sarlo GL2Holton KF3,4.

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Ketamine and magnesium common pathway of antidepressant action.

Magnes2018 May 1;31(2):33-38. doi: 10.1684/mrh.2018.0440.
Górska N1Cubała WJ1Słupski J1Gałuszko-Węgielnik M1.

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Magnesium in addiction - a general view.

Magnes2018 Aug 1;31(3):90-98. doi: 10.1684/mrh.2018.0443.
Nechifor M1.

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Dietary magnesium deficiency alters gut microbiota and leads to depressive-like behaviour.

Acta Neuropsychiatr.2015 Jun;27(3):168-76. doi: 10.1017/neu.2015.7. Epub 2015 Feb 18.
Winther G1Pyndt Jørgensen BM2Elfving B1Nielsen DS3Kihl P2Lund S4Sørensen DB2Wegener G1.

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AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in the forced swim test.

Int J Neuropsychopharmacol, 2004, 7, 387–390.
Gould TD, Einat H, Bhat R, Manji HK

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Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus.

Biol Psychiatry, 2004, 55, 781–784.
Kajdanovich-Beilin O, Milman A, Weizman A, Pick CG, Eldar-Finkelman H

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Antidepressant activity of zinc and magnesium in view of the current hypotheses of antidepressant action

Bernadeta Szewczyk1,*, Ewa Poleszak3,*, Magdalena Sowa-Kuæma1, Marcin Siwek4, Dominika Dudek4, Beata Ryszewska-Pokraœniewicz5, Maria Radziwoñ-Zaleska5, W³odzimierz Opoka7, Janusz Czekaj6, Andrzej Pilc1,6, Gabriel Nowak1,2 Pharmacological Reports 2008, 60, 588–599 ISSN 1734-1140

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Dietary magnesium intake and risk of depression.

J Affect Disord.2019 Mar 1;246:627-632. doi: 10.1016/j.jad.2018.12.114. Epub 2018 Dec 27.
Sun C1Wang R2Li Z1Zhang D3.

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Role of magnesium supplementation in the treatment of depression: A randomized clinical trial.

PLoS2017 Jun 27;12(6):e0180067. doi: 10.1371/journal.pone.0180067. eCollection 2017.
Tarleton EK1Littenberg B1,2MacLean CD1,2Kennedy AG1,2Daley C3.

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The Effects of Magnesium Supplementation on Subjective Anxiety and Stress-A Systematic Review.

2017 Apr 26;9(5). pii: E429. doi: 10.3390/nu9050429.
Boyle NB1Lawton C2Dye L3.

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The effects of magnesium supplementation on subjective anxiety.

Magnes2016 Mar 1;29(3):120-125.
Boyle NB1Lawton CL1Dye L1.

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Complementary and Alternative Medicine Treatments for Generalized Anxiety Disorder: Systematic Review and Meta-analysis of Randomized Controlled Trials.

Adv Ther.2018 Mar;35(3):261-288. doi: 10.1007/s12325-018-0680-6. Epub 2018 Mar 5.
Barić H1Đorđević V2Cerovečki I3Trkulja V4.

Folic Acid:

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Enhancement of antidepressant action of fluoxetine by folic acid: a randomised placebo control trial.

Journal od Affective Disorders, Nov 2000, pp121—130

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Treatment of depression: time to consider folic acid and B12.

Journal of Psychopharmacology, Jan 1 2005
“There is now evidence of a common decrease in folic acid and B12, an increase homocysteine and polymorphism of MTHFR C677T being overrepresented in depressive patients”

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Enhancement of recovery from mental illness with L-methylfolate supplementation.

Perspective Psychiatric Care: 2018 April 54[2], pp331—334

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Folate in unipolar depressive illness, a systematic review and meta-analysis.

J Psychopharmacology: 2018. April:32 [4] pp377—384

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Folate in depression: efficacy, safety, differences in formulations, and clinical issues.

J Clin Psychiatry 2009;70 Suppl 5:12-17. [Full text]
Fava M, Mischoulon D. 

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The role of folic acid in the prevention and treatment of depression: An overview of existing evidence and implications for practice

Chrystalleni Lazarou a,*, Margarita Kapsou b
Harokopio University, Department of Nutrition and Dietetics, Athens, Greece
University of Cyprus, Department of Psychology, Nicosia, Cyprus
 
Article in Complementary therapies in clinical practice · August 2010
DOI: 10.1016/j.ctcp.2010.01.003 · Source: PubMed

Pyridoxine:

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Pyridoxine and the premenstrual syndrome: a randomised crossover trial.

British Journal of General Practice. 1989: 39[326] 364—368
Conclusion: There was a statistically significant benefit in depression, irritability and tiredness in the treated group.

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Antidepressive effect of pyridoxine in neuroleptic treated schizophrenic patients with co-morbid depression

Harefuah [Israel] May 2001: 140 [5]; 369—373.
Conclusion: A subgroup of schizophrenic patients with co-morbid depression may benefit from pyridoxine added to their anti-psychotic treatment

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B Complex Vitamin Patterns in Geriatric and Young Adult In patients with Major Depression.

Journal of American Geriatrics Society: March 1991: Vol 39 issue 3
Conclusion: A poorer status of B Vitamins is present in major depression.

E

Peripheral neuropathy with hypervitaminosis B6 caused by self-medication

Rev Med Interne. 2019 Nov 30. pii: S0248-8663(19)31146-4. doi: 10.1016/j.revmed.2019.11.003. [Epub ahead of print] [Article in French]
Malet L1, Dayot L2, Moussy M3, de la Gastine B2, Goutelle S4.

Vitamin D:

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Vitamin D in schizophrenia: a clinical review.

Evid Based Ment Health. 2016 Feb;19(1):6-9. doi: 10.1136/eb-2015-102117. Epub 2016 Jan 14.
Chiang M1, Natarajan R1, Fan X2.

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Vitamin D and depression.

J Affect Disord.2017 Jan 15;208:56-61. doi: 10.1016/j.jad.2016.08.082. Epub 2016 Oct 11.
Parker GB1Brotchie H2Graham RK2

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Efficacy of vitamin D supplementation in major depression: A meta-analysis of randomized controlled trials.

J Postgrad Med.2018 Jun 21. doi: 10.4103/jpgm.JPGM_571_17. [Epub ahead of print]

Vellekkatt F1Menon V1

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Vitamin D is a potential antidepressant in psychiatric outpatients.

Int J Clin Pharmacol Ther.2018 Dec;56(12):585-596. doi: 10.5414/CP203309.
Abdul-Razzak KKAlmanasrah SOObeidat BAKhasawneh AG

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Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.

Am J Psychiatry.2016 Jun 1;173(6):575-87. doi: 10.1176/appi.ajp.2016.15091228. Epub 2016 Apr 26.
Sarris J1Murphy J1Mischoulon D1Papakostas GI1Fava M1Berk M1Ng CH1

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Association of antepartum vitamin D deficiency with postpartum depression: a clinical perspective.

Public Health Nutr.2019 Jan 18:1-6. doi: 10.1017/S136898001800366X. [Epub ahead of print]
Szpunar MJ1

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Non-cardiac Chest Pain and Anxiety: A Possible Link to Vitamin D and Calcium.

J Clin Psychol Med Settings.2018 Aug 27. doi: 10.1007/s10880-018-9579-2. [Epub ahead of print]
Alkhatatbeh MJ1Abdul-Razzak KK2Amara NA2Al-Jarrah M3.

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Vitamin D in anxiety and affective disorders.

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Database Analysis of Depression and Anxiety in a Community Sample-Response to a Micronutrient Intervention.

2018 Jan 30;10(2). pii: E152. doi: 10.3390/nu10020152.
Kimball SM1,2Mirhosseini N3Rucklidge J4

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Vitamin D and probiotic co-supplementation affects mental health, hormonal, inflammatory and oxidative stress parameters in women with polycystic ovary syndrome.

J Ovarian Res.2019 Jan 21;12(1):5. doi: 10.1186/s13048-019-0480-x.
Ostadmohammadi V1Jamilian M2Bahmani F1Asemi Z3

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Prevalence of Vitamin D Deficiency in Adult Outpatients With Bipolar Disorder or Schizophrenia.

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Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, part 2: relevance for ADHD, bipolar disorder, schizophrenia, and impulsive behavior.

FASEB J.2015 Jun;29(6):2207-22. doi: 10.1096/fj.14-268342. Epub 2015 Feb 24.
Patrick RP1Ames BN1

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Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Psychiatry Res.2018 Dec;270:104-110. doi: 10.1016/j.psychres.2018.09.024. Epub 2018 Sep 13.
Fond G1Godin O2Schürhoff F et al

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Vitamin D Supplementation in Chronic Schizophrenia Patients Treated with Clozapine: A Randomized, Double-Blind, Placebo-controlled Clinical Trial.

EBioMedicine.2017 Dec;26:138-145. doi: 10.1016/j.ebiom.2017.11.027. Epub 2017 Dec 2.
Krivoy A1Onn R2Vilner Y3, et al

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Hypovitaminosis D is associated with negative symptoms, suicide risk, agoraphobia, impaired functional remission, and antidepressant consumption in schizophrenia.

Eur Arch Psychiatry Clin Neurosci.2018 Aug 4. doi: 10.1007/s00406-018-0932-0. [Epub ahead of print]
Fond G1,2,3Faugere M4,5,6Faget-Agius C4,5,6,et al

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Hypovitaminosis D is associated with depression and anxiety in schizophrenia: Results from the national FACE-SZ cohort.

Psychiatry Res.2018 Dec;270:104-110. doi: 10.1016/j.psychres.2018.09.024. Epub 2018 Sep 13.
Fond G1Godin O2Schürhoff F et al

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Vitamin D Supplementation in Chronic Schizophrenia Patients Treated with Clozapine: A Randomized, Double-Blind, Placebo-controlled Clinical Trial.

EBioMedicine.2017 Dec;26:138-145. doi: 10.1016/j.ebiom.2017.11.027. Epub 2017 Dec 2.
Krivoy A1Onn R2Vilner Y3, et al

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Association Between Vitamin D Insufficiency and Metabolic Syndrome in Patients With Psychotic Disorders.

Psychiatry Investig.2018 Apr;15(4):396-401. doi: 10.30773/pi.2017.08.30. Epub 2018 Feb 28.
Yoo T1Choi W2Hong JH3Lee JY1,3,4Kim JM1Shin IS1Yang SJ5Amminger P6Berk M6,7Yoon JS1Kim SW1,3,4

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The association between neonatal vitamin D status and risk of schizophrenia.

Sci Rep.2018 Dec 6;8(1):17692. doi: 10.1038/s41598-018-35418-z.
Eyles DW1,2Trzaskowski M3Vinkhuyzen AAE3, et al

E

Vitamin D in schizophrenia: a clinical review.

Evid Based Ment Health. 2016 Feb;19(1):6-9. doi: 10.1136/eb-2015-102117. Epub 2016 Jan 14.
Chiang M1, Natarajan R1, Fan X2.

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Vitamin D levels, brain volume, and genetic architecture in patients with psychosis.

PLoS2018 Aug 24;13(8):e0200250. doi: 10.1371/journal.pone.0200250. eCollection 2018.
Berg AO1,2Jørgensen KN1,3Nerhus  M et al

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Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study.

Schizophr2018 Aug 25. pii: S0920-9964(18)30503-6. doi: 10.1016/j.schres.2018.08.011. [Epub ahead of print]
Lally J1Ajnakina O2Singh N3Gardner-Sood P4Stubbs B5Stringer D6Di Forti M7David AS8Smith S9Murray RM10Howes OD11Gaughran F12.

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C-Reactive Protein as a Peripheral Biomarker in Schizophrenia. An Updated Systematic Review.

Front Psychiatry.2018 Aug 23;9:392. doi: 10.3389/fpsyt.2018.00392. eCollection 2018.
Fond G1Lançon C1Auquier P1Boyer L1

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Upregulation of vitamin D-related genes in schizophrenic patients.

Neuropsychiatr Dis Treat.2018 Oct 9;14:2583-2591. doi: 10.2147/NDT.S176301. eCollection 2018.
Asadzadeh Manjili F1Kalantar SM2Arsang-Jang S3Ghafouri-Fard S4Taheri M4,5Sayad A4

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Inflammatory biomarkers in psychosis and clinical high risk populations.

Schizophr Res. 2018 Nov 8. pii: S0920-9964(18)30619-4. doi: 10.1016/j.schres.2018.10.017.

[Epub ahead of print]
Delaney S1Fallon B2Alaedini A3Yolken R4Indart A3Feng T5Wang Y5Javitt D2.

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The Role of Vitamin D in Brain Health: A Mini Literature Review.

Cureus.2018 Jul 10;10(7):e2960. doi: 10.7759/cureus.2960.
Anjum I1Jaffery SS2Fayyaz M3Samoo Z4Anjum S5

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Vitamin D, Folate and the Intracranial Volume in Schizophrenia and Bipolar Disorder and Healthy Controls.

Sci Rep.2018 Jul 17;8(1):10817. doi: 10.1038/s41598-018-29141-y.
Gurholt TP1,2Osnes K3Nerhus M4,5Jørgensen KN4,3Lonning V4,3Berg AO4,6Andreassen OA4,6Melle I4,6Agartz I4,3,7

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Bipolar disorder in youth is associated with increased levels of vitamin D-binding protein.

Transl2018 Mar 13;8(1):61. doi: 10.1038/s41398-018-0109-7.
Petrov B1Aldoori A1James C2Yang K1,3Algorta GP4Lee A1Zhang L2Lin T5Awadhi RA6Parquette JR5Samogyi A2Arnold LE7Fristad MA7Gracious B7,8Ziouzenkova O9

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Exploring the relationship between vitamin D and mania: correlations between serum vitamin D levels and disease activity.

Nord J Psychiatry.2018 Apr;72(3):221-225. doi: 10.1080/08039488.2018.1424238. Epub 2018 Jan 7.
Altunsoy N1Yüksel RN1Cingi Yirun M1Kılıçarslan A2Aydemir Ç1.

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Vitamin D3 Supplemental Treatment for Mania in Youth with Bipolar Spectrum Disorders.

J Child Adolesc Psychopharmacol.2015 Jun;25(5):415-24. doi: 10.1089/cap.2014.0110.
Sikoglu EM1,2,3Navarro AA1,2,3,4Starr D2,3, et al

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Micronutrient intake adequacy and depression risk in the SUN cohort study.

Eur J Nutr.2018 Oct;57(7):2409-2419. doi: 10.1007/s00394-017-1514-z. Epub 2017 Sep 4.
Sánchez-Villegas A1,2Pérez-Cornago A3Zazpe I4,5Santiago S5Lahortiga F6Martínez-González MA4,7,8.

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Association between Serum Vitamin Levels and Depression in U.S. Adults 20 Years or Older Based on National Health and Nutrition Examination Survey 2005⁻2006.

Int J Environ Res Public Health.2018 Jun 9;15(6). pii: E1215. doi: 10.3390/ijerph15061215.
Huang X1,2Fan Y3,4Han X5,6Huang Z7,8Yu M9,10Zhang Y11,12Xu Q13,14Li X15,16Wang X17,18Lu C19,20Xia Y21,22

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Are plasma 25-hydroxyvitamin D and retinol levels and one-carbon metabolism related to metabolic syndrome in patients with a severe mental disorder?

Psychiatry Res.2019 Jan 3;273:22-29. doi: 10.1016/j.psychres.2019.01.005. [Epub ahead of print]
Arranz B1Sanchez-Autet M2San L3Safont G4Fuente-Tomás L5Hernandez C6Bogas JL6García-Portilla MP5.

SAMe:

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Ethanol lowers glutathione in rat liver and brain and inhibits methionine synthase in a cobalamin-dependent manner.

E

Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence.

Am J Clin Nutr.2002 Nov;76(5):1158S-61S.
Mischoulon D1Fava M

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Excessive S-Adenosyl-L-Methionine-Dependent Methylation Increases Levels of Methanol, Formaldehyde and Formic Acid in Rat Brain Striatal Homogenates: Possible role in S-adenosyl-L-methionine-induced Parkinson’s disease-like disorders.

E

Effects of chronic administration of S-adenosyl-L-methionine on brain oxidative stress in rats.

E

Effect of S-adenosyl-L-methionine on rat brain oxidative stress damage in a combined model of permanent focal ischemia and global ischemia-reperfusion.

E

Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence.

Mischoulon D, Fava M. Am J Clin Nutr. 2002;76(5):1158S–1161S.

E

Folates and S-adenosylmethionine for major depressive disorder.

Papakostas GI, Cassiello CF, Iovieno N. Can J Psychiatry. 2012 Jul;57(7):406–13.

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Evidence for S-adenosyl-L-methionine (SAM-e) for the treatment of major depressive disorder.

J Clin Psychiatry.2009;70 Suppl 5:18-22. doi: 10.4088/JCP.8157su1c.04.
Papakostas GI1

E

Folate in depression: efficacy, safety, differences in formulations, and clinical issues.

Fava M, Mischoulon D. J Clin Psychiatry 2009;70 Suppl 5:12-17. 

E

Homocysteine, folate, methylation, and monoamine metabolism in depression

E

S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.

Bressa GM. Acta Neurol Scand Suppl. 1994;154:7–14. [PubMed]

E

S-Adenosyl-L-Methionine (SAMe) for Depression, Osteoarthritis and Liver Disease.

Hardy M, Coulter I, Morton SC, et al.  Agency for Healthcare Research and Quality; Rockville, MD: Aug, 2002.

E

Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies.

Delle Chiaie R, Pancheri P, Scapicchio P. Am J Clin Nutr. 2002 Nov;76(5):1172S–6S.

E

Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.

Am J Psychiatry.2016 Jun 1;173(6):575-87. doi: 10.1176/appi.ajp.2016.15091228. Epub 2016 Apr 26.
Sarris J1Murphy J1Mischoulon D1Papakostas GI1Fava M1Berk M1Ng CH1

E

Is S-Adenosyl Methionine (SAMe) for Depression Only Effective in Males? A Re-Analysis of Data from a Randomized Clinical Trial.

Sarris J, Price LH, Carpenter LL, Tyrka AR, Ng CH, Papakostas GI, et al. Pharmacopsychiatry. 2015 Jul;48(4–5):141–4.

E

A comprehensive review on the efficacy of S-Adenosyl-L-methionine in Major Depressive Disorder.

E

S-adenosylmethionine (SAMe) as treatment for depression: a systematic review.

Williams AL, Girard C, Jui D, et al. Clin Invest Med 2005;28(3):132-139. [Abstract]

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S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine.

Alpert JE, Papakostas G, Mischoulon D, et al. J Clin Psychopharmacol 2004;24(6):661-664

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Adjunctive S-adenosylmethionine (SAMe) in treating non-remittent major depressive disorder: An 8-week double-blind, randomized, controlled trial.

Eur Neuropsychopharmacol.2018 Oct;28(10):1126-1136. doi: 10.1016/j.euroneuro.2018.07.098. Epub 2018 Aug 14.
Sarris J1Byrne GJ2Bousman C3, et al

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Clinical use of nutraceuticals in the adjunctive treatment of depression in mood disorders.

Australas2017 Aug;25(4):369-372. doi: 10.1177/1039856216689533. Epub 2017 Jan 31.
Sarris J1

E

S-adenosyl methionine (SAMe) for depression in adults.

E

S-Adenosyl-Methionine improves depression in patients with Parkinson's disease in an open-label clinical trial.

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Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder.

Eur Psychiatry.2012 Oct;27(7):518-21. doi: 10.1016/j.eurpsy.2011.03.006. Epub 2011 Jun 12.
Levkovitz Y1Alpert JEBrintz CEMischoulon DPapakostas GI

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Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder.

Levkovitz Y, Alpert JE, Brintz CE, et al. J Affect Disord. 2012;136(3):1174–1178.

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Improvement of aggressive behavior and quality of life impairment following S-adenosyl-methionine (SAM-e) augmentation in schizophrenia.

Eur Neuropsychopharmacol.2009 Jan;19(1):14-22. doi: 10.1016/j.euroneuro.2008.08.004. Epub 2008 Sep 27.
Strous RD1Ritsner MSAdler SRatner YMaayan RKotler MLachman HWeizman A

E

The switch mechanism and the bipolar/unipolar dichotomy.

Carney MW, Chary TK, Bottiglieri T, Reynolds EH. Br J Psychiatry J Ment Sci. 1989 Jan;154:48–51.

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S-Adenosyl-L-Methionine (SAMe) for Depression, Osteoarthritis and Liver Disease.

Agency for Healthcare Research and Quality; Rockville, MD: Aug, 2002.
Hardy M, Coulter I, Morton SC, et al. 

E

Psychological distress during the puerperium: a novel therapeutic approach using S-adenosylmethionine.

Ther. Res. 1993;53:701–716.
Cerutti R, Sichel MP, Perin M, et al.

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Role of S-adenosyl-L-methionine in the treatment of depression: a review of the evidence.

Mischoulon D, Fava M. Am J Clin Nutr. 2002;76(5):1158S–1161S. [PubMed]

E

S-adenosyl-l-methionine (SAMe) as antidepressant: meta-analysis of clinical studies.

Bressa GM. Acta Neurol Scand Suppl. 1994;154:7–14. [PubMed]

E

S-Adenosyl-L-Methionine (SAMe) for Depression, Osteoarthritis and Liver Disease.

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