Bio Balance Health introduced the Pyrroles in urine test to Australia in 2004 and has since continued to support the refinement and accuracy through ongoing research and clinical observations.  However, it’s crucial to acknowledge the following disclaimer:

The only known accurate source of information regarding Pyrroles, including research findings, is available exclusively on our official channels and the AAL website.  Why? We have done the work of identifying the molecules involved in this test, and providing a distinct measure for pyrroles in urine.

It is essential to note that the accuracy of the Pyrroles in urine test is contingent upon the laboratory conducting the analysis.  BBH informs you that the only known laboratory providing an accurate test is Applied Analytical Laboratories (AAL) https://www.apanlabs.com/urinary-pyrrole-test/.  Other laboratories, may include a major portion of the combined figure is likely Urobilinogen, a gut by product.

It is the responsibility of medical and health practitioners to ensure their treatment plans are based on accurate and reliable information.

Published Research

In line with our commitment to advancing knowledge in this field, we are pleased to share the following published research from February 2023:

Pyrroles as a Potential Biomarker for Oxidative Stress Disorders
by Brett Lambert, Annalese Semmler, Cristina Beer and Joanne Voisey
https://bit.ly/IJMS-PyrrolesOxidativeStressBiomarker

This research explores the potential of Pyrroles as biomarker for oxidative stress disorders, and their role in identifying biochemical imbalances associated with various disorders, including bile disorders.

Pyrroles have for many years served as an indicator of mental health issues. Prior to pyrrole testing, it was difficult to accurately measure the severity of mental health challenges in individuals. With advancements in modern technology, we can also distinguish urobilinogen as a separate measure distinct from the pyrrole measure. This increases the understanding of physiological functions.

Practitioners trained in interpreting pyrrole levels can now develop personalised management plans tailored to each individual’s needs. Monitoring the reduction in pyrrole count, combined with reduction in symptoms, serves as a reliable indicator of the effectiveness of their plan. Individuals who have seen their pyrrole levels decrease to near-normal levels report experiencing a significant improvement in their overall well-being.

Getting better does not take overnight. Some individuals may require ongoing managing long-term, while others may experience rapid improvement and only need to address pyrrole levels at times of heightened stress.

Subscribe to view the Science of Pyrroles in Urine online lecture .

Pyrrole production occurs when the body fails to break down old blood products properly, signalling a stress response. This stress could be triggered from various factors, and is very individual. For some individuals, it may be from financial stress, a poor diet, workplace pressure, bullying, or exposure to toxic substances. Pyrroles in urine serves as a biomarker measure indicating the severity of this stress response.

The approach? Addressing the root cause of pyrrole production to alleviate symptoms.  Those fortunate to consult a doctor who understands the significance of pyrroles in urine have reported significant relief.

For more indepth information about pyrroles, and urine collection protocols for accurate results, visit the AAL website:  https://www.apanlabs.com/ .

To locate a doctor near you who understands pyrroles, visit our doctor page.

Consider donating to our original research projects, which aim to further enhance the benefits of this test worldwide, and assist more individuals facing unresolved health issues.

Note. Not all mental health is associated with a high urinary pyrroles measure. For those experiencing elevated pyrroles, understanding the underlying cause offers reassurance and the opportunity for practical intervention.

These are all terms used to describe a chemical found in the urine. This compound has been clinically linked to various chronic mental health issues.

However, it’s important to note that while this compound serves as a biomarker, no conclusive research has labelled it as a distinct condition, syndrome, disorder, or genetic trait.

Our research findings indicate:

• The presence of Pyrroles in Urine serves as a biomarker for measuring oxidative stress levels, rather than providing a definitive diagnosis. Managing this stress is crucial for long-term symptom reduction, alongside the rebalancing of biochemistry and quenching of ROS.
• The accurate terminology for this biomarker is “High” or “Elevated Urinary Pyrroles”.
• Due to the instability of Urinary Pyrroles, it is imperative that urine collection and transportation adhere to strict standardized protocols to ensure the reliability of test results. Inadequate collection and handling procedures may result in false readings.

By understanding the nature of Urinary Pyrroles and adhering to rigorous testing standards, healthcare professionals can better assess oxidative stress levels and tailor treatment plans accordingly.

The only dedicated Pyrroles in Urine testing laboratory in Australia is Applied Analytical Laboratories Pty Ltd (AAL). AAL is the leader in investigating the origin of elevated urinary pyrroles and gives separate measures for pyrroles and urobilinogen.

In 2018, Applied Analytical Laboratories, an Australian laboratory, made a significant advancement by incorporating the measurement of urobilinogen in their testing process.  Urobilinogen, a by-product of normal gut function, is co-measured alongside Pyrroles in the assay.  The ability to separate these urine components is crucial for identifying additional pathologies, such as obstructed bile duct, haemolytic anaemia, or hepatitis, ensuring correct interpretation. This distinction is vital as falsely treated results can exacerbate symptoms and/or lead to vitamin B6 toxicity.

The AAL laboratory report provides clear reference ranges for both Urobilinogen and Pyrroles, and measure for other parameters.

Support our research on High Urinary Pyrroles by donating today.  Your contribute will help further understanding and gain recognition by the broader medical community.  If you’ve experienced the benefits of understanding how urinary pyrrole levels affect health, consider making a difference for others.  Your donation is tax-deductible, and even small contributions can make a significant impact on our research efforts.  Visit our donation page to contribute.

For optimal results, consult a doctor trained by Bio Balance Health. Self-diagnosis and self-medication may not achieve optimal results.

The following are references from Australian Research which has advanced understanding of measuring urinary pyrrole.  Applied Analytical Laboratories data has been used and/or they have actively participated in the studies published in 1,2,3,6 & 7 below, and are currently involved in ongoing research.

¹ Biomarkers of a five-domain translational substrate for schizophrenia and schizoaffective psychosis.
Biomark Res. 2015 Feb 6;3:3. doi: 10.1186/s40364-015-0028-1. eCollection 2015.
Fryar-Williams S¹, Strobel JE. 

² Fundamental Role of Methylenetetrahydrofolate Reductase 677 C → T Genotype and Flavin Compounds in Biochemical Phenotypes for Schizophrenia and Schizoaffective Psychosis.
Biomark Res. 2016 Nov 9;7:172. eCollection 2016.
Fryar-Williams S 

³ Biomarker Case-Detection and Prediction with Potential for Functional Psychosis Screening: Development and Validation of a Model Related to Biochemistry, Sensory Neural Timing and End Organ Performance.
Front Psychiatry. 2016 Apr 14;7:48. doi: 10.3389/fpsyt.2016.00048. eCollection 2016.
Fryar-Williams S¹, Strobel JE.

⁴ Nutritional interventions in clinical depression.
Clinical Psychological Science, 2016. Vol. 4(1), 144-162,
Rechenberg, K. (2015)

⁵ Does the usual dietary intake of patients with depression require vitamin mineral supplementation?
Psychiatr. Pol 2014; 48(1): 75-88,
Stefańska E, Wendołowicz A, Kowzan U, Konarzewska B, Szulc A, Ostrowska L.

⁶ “The Effectiveness of Targeted Nutrient Therapy In Treatment of Mental Illness – A Pilot Study”;
ACNEM Journal, Vol 29 No.3, 2010
Richard Stuckey, William Walsh, Brett Lambert.

⁷ Micronutrient Therapy for Violent and Aggressive Male Youth: An Open Label Trial
Journal of Child & Adolescent Psychopharmacology, 2017 Nov; 27(9): 823-832;
Hambly, J., Francis, K., Khan, S., Gibbons, K., Walsh, W., Lambert, B., Testa, C., & Haywood, A., doi: 10.1089/cap.2016.0199. Epub 2017 May 8.

⁸ Pyrroles as a Potential Biomarker for Oxidative Stress Disorders
Brett Lambert, Annalese Semmler, Cristina Beer and Joanne Voisey
https://bit.ly/IJMS-PyrrolesOxidativeStressBiomarker