Brett Lambert, Applied Analytical Laboratories

The Science of Pyrroles in Urine

How one non-invasive test can indicate differential diagnosis for physiological changes presenting as mental health symptoms, and also demonstrate treatment response.

Urine-Pyrrole-Test-Apan Labs


Pyrroles are not normally found in the urine of healthy people. Its presence tells us the body is under stress. The amount of pyrrole is proportional to the stress. The change in the amount can indicate treatment response.

Bio Balance Health have developed, and supported, world leading original research which has confirmed pyrroles in urine are a biomarker of oxidative stress.  It is not a diagnosis, genetic or condition.

Urobilinogen is found in small amounts in healthy people. High levels may be associated with impaired kidney function, and its absence may indicate gallstones or biliary blockage. Both levels can present with mental health like symptoms, eg anxiety, behavioural issues.

Bio Balance Health’s responsibility is to understand why toxicity occurs and how to manage it.

By asking the questions:

  • What are we measuring, and why?
  • What is the perceived association between pyrroles in urine and B6?
  • What are the interferences in this test?

Because of assay technique all previous observations (other than AAL) have been based on the measurement of Urobilinogen, and not Pyrrole. (Ref: The Science of Pyrrole Lecture)

Therefore, symptom relationships are not yet verified. For example: Cold water immersion experiments measured urobilinogen – not the pyrrole and the physiology will confirm this (Refer to Pyrrole lecture)

Please note: Previous descriptions/ symptoms/ causes of “Pyrroles/ Pyrroluria” are scientifically incorrect or not validated. The proven science provides much more data.

This lecture also presents our research on the 800MHz NMR on the pyrrole in urine complex which has shown it is not chemically possible for B6 to be stripped out by pyrroles. Nor does it strip out Zinc.

Training for doctors is available through BBH. For more information see:

The lecture on The Science of Pyrroles in Urine is available here:

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