General Public

Mental Health Biochemistry & Nutrients

The famous Dr Carl Pfeiffer once stated that: “For every drug that benefits a patient, there is a natural substance that can achieve the same effect.”

The Bio Balance Health core program originated in America in the 1980’s and 1990’s by Psychiatrist Dr Carl Pfeiffer and Chemical Engineer and mathematician, William J Walsh PhD. Using Dr Pfeiffer’s clinical observations, Dr Bill Walsh was able to apply his chemistry expertise, and his mathematical ability to identify clinical clusters. Initially the clusters were described around symptoms and now, because of modern technology, are described around the biochemistry.


For many years researchers and clinicians have felt that there is a relationship between sub optimal function of the methylation pathway and mental health.

Overmethylation and Undermethylation

These are descriptors applied within the Pfeiffer/Walsh Clinic in Chicago to describe a clear difference they observed in the patients attending the clinic. The descriptors are very useful in the clinic setting to describe to patients the basic reason for their specific biochemistry. They are not however accurate scientific terms.  With modern equipment and technology, research is in process aimed to illuminate the actual science. The core difference to be remembered is that individuals respond to different biochemistry and if prescribed the incorrect nutrient it may exacerbate symptoms and complicate recovery. Methylation issues are not related to Pyrrole measurements.

Pyrrole Kryptopyrrole


Pee tells you lots of things.

We all know pee can be a warning sign. If pee is yellow you are likely to be dehydrated. If it’s clear you know you’ve drunk enough water Pee can show a lot more warnings. For example infections of the bladder.

Another warning sign that pee can give is pyrrole. Pyrrole in your urine  can tell you that there may be trouble in some internal workings of the body, may be in your liver, which may be making you feel all sorts of emotions. Another one is urobilinogen, which comes from bile. Too much or too little urobilinogen can be a warning sign of gut problems.

Anxiety & Depression


Anyone can feel sad, moody or low at times, but some people experience these feelings intensely, for long periods of time (weeks, months or even years) and sometimes without any apparent reason. Depression is more than just a low mood – it’s a serious condition that affects your physical and mental health.

Biochemical imbalances can contribute to Depression. Research suggests that depression doesn’t spring from simply having too much or too little of certain brain chemicals. There are many possible causes of depression, including faulty mood regulation by the brain, genetic vulnerability, stressful life events, medications, and medical problems. It’s believed that several of these forces may compound to trigger depression.

Gut & Mental Health

Increasing evidence has linked gut microbiota to both gastrointestinal and extra-gastrointestinal diseases. Dysbiosis and inflammation of the gut have been linked to causing several mental illnesses including anxiety and depression, which are prevalent in society today. Researchers say controlling the bacterial population of the gastrointestinal tract may help improve symptoms of mental disorders.

Knowing which foods can contribute to a healthy gut and which can potentially cause problems is a great place to start. Try replacing highly processed, high-sugar, and high-fat foods with various whole foods that offer myriad benefits.


Bipolar disorder is a mental illness marked by extreme shifts in mood. Symptoms can include an extremely elevated mood called mania. They can also include episodes of depression. Bipolar disorder is also known as bipolar disease or manic depression.

Bipolar disorder can have two extremes: up and down. To be diagnosed with bipolar, you must experience a period of mania or hypomania. People generally feel “up” in this phase of the disorder. When you’re experiencing an “up” change in mood, you may feel highly energized and be easily excitable.


Schizophrenia is a chronic and severe brain disorder in which people interpret reality abnormally. It can cause many symptoms including hallucinations (hearing voices or seeing things that are not there), paranoia, delusions (fixed, false beliefs) or a reduced ability to express emotions.

Certain biochemical substances in the brain are believed to be involved in schizophrenia, especially a neurotransmitter called dopamine. Even though biochemical imbalances may contribute to a Schizophrenia diagnosis, stigma and discrimination of people with schizophrenia is still common.

Post Natal Depression

Post Natal Depression occurs at a time when there should be much joy as a new child is welcomed. It is a debilitating mental health condition which has major impact on the relationship between a child and their family.

Obsessive Compulsive Disorder (OCD

Obsessive-compulsive disorder (OCD) is characterized by repetitive, unwanted thoughts (obsessions) and irrational, excessive urges to do certain actions (compulsions). Although people with OCD may know that their thoughts and behaviours don’t make logical sense, they’re often unable to stop them.

Suicide and Biochemistry

Suicide and suicidal tendencies are often hidden as a mental health condition by sufferers.

Bio Balance Health sponsored clinical observation studies and literature reviews supports the view that biochemistry imbalances may be observed if adequate testing of these parameters occurred.

Autism Spectrum Disorder

Autism and autism spectrum disorders (ASD) are diseases which are characterized by physical (neurological function and pathology) and behavioral (social interaction) abnormalities that are most commonly diagnosed in children. Autism affects how a person thinks, feels, interacts with others, and experiences their environment.

Attention-Deficit/Hyperactivity Disorder (ADHD)

ADHD is a neurodevelopmental condition that can affect family life. The word “neurodevelopmental” refers to the nervous system which includes the brain as it develops across the lifespan. ADHD behaviour usually appears by age seven though difficult behaviour may show up before this. With ADHD, children can have trouble with impulsivity, hyperactivity, distractedness, following instructions and completing tasks.